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ALFUSIN-D (ALFUZOSIN/DUTASTERIDE) TABLETS: PATIENT INFORMATION
Patients should be told about the possible occurrence of symptoms related to postural hypotension, such as dizziness, when beginning alfuzosin which is one of the component of Alfusin-D tablets, and they should be cautioned about driving, operating machinery, or performing hazardous tasks during this period. This is important for those with low blood pressure or who are taking antihypertensive medications or nitrates.
Patients should be instructed to tell their ophthalmologist about their use of Alfusin-D tablets before cataract surgery or other procedures involving the eyes, even if the patient is no longer taking alfuzosin hydrochloride.
Patients should be advised about the possibility of priapism resulting from treatment with alfuzosin which is one of the component of Alfusin-D tablets and medications in the same class. Although this reaction is extremely rare, if it is not brought to immediate medical attention, it can lead to permanent erectile dysfunction (impotence).
Physicians should inform patients that dutasteride reduces serum PSA levels by approximately 50% within 3-6 months of therapy, although it may vary for each individual. For patients undergoing PSA screening, increases in PSA levels while on treatment with dutasteride may signal the presence of prostate cancer and should be evaluated.
Physicians should inform patients that there was an increase in high-grade prostate cancer in men treated with 5 alpha-reductase inhibitors (which are indicated for BPH treatment), including dutasteride, compared with those treated with placebo in studies looking at the use of these drugs to reduce the risk of prostate cancer.
Physicians should inform patients that Alfusin-D tablets containing dutasteride as it's one of the component should not be handled by a woman who is pregnant or who could become pregnant because of the potential for absorption of dutasteride and the subsequent potential risk to a developing male foetus. Dutasteride is absorbed through the skin and could result in unintended foetal exposure. If a pregnant woman or woman of childbearing potential comes in contact with broken Alfusin-D tablet, the contact area should be washed immediately with soap and water.
Physicians should inform men treated with Alfusin-D tablets containing dutasteride as it's one of the component, should not donate blood until at least 6 months following their last dose, so as to prevent pregnant women from receiving dutasteride through blood transfusion. Serum levels of dutasteride are detectable for 4-6 months after treatment ends.
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